Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis
نویسندگان
چکیده
منابع مشابه
CDR2L Antibodies: A New Player in Paraneoplastic Cerebellar Degeneration
OBJECTIVE Yo antibodies are associated with paraneoplastic cerebellar degeneration (PCD). We have characterized Yo sera by measuring CDR2 and CDR2L antibodies and the localization of their antigens. METHODS Forty-two Yo sera from patients with paraneoplastic neurological syndromes (PNS), 179 sera from ovarian and 114 sera from breast cancer patients without PNS and 100 blood donors were scree...
متن کاملOnconeural antibodies with special reference to anti-Yo
..............................................................................................................7 LIST OF PUBLICATIONS.........................................................................................9 ABBREVIATIONS...................................................................................................10 1. THE IMMUNE SYSTEM .........................................
متن کاملCalcium, Synaptic Plasticity and Intrinsic Homeostasis in Purkinje Neuron Models
We recently reproduced the complex electrical activity of a Purkinje cell (PC) with very different combinations of ionic channel maximum conductances, suggesting that a large parameter space is available to homeostatic mechanisms. It has been hypothesized that cytoplasmic calcium concentrations control the homeostatic activity sensors. This raises many questions for PCs since in these neurons c...
متن کاملANTICONVULSANT THERAPY-INDUCED ALTERATIONS IN CALCIUM HOMEOSTASIS
35 epileptic patients, aged 10 to 58 years (mean 23), who were taking anticonvulsant drugs were studied. The patients exhibited a 34% reduction in serum calcium levels, a 41 % increase in serum alkaline phosphatase activity and a slight but insignificant decrease in serum phosphate, compared to untreated controls. These changes appear to be related to the anticonvulsant drug taken, in the ...
متن کاملParaneoplastic cerebellar degeneration and anti-Yo antibodies.
a Servicio de Neurología, Hospital Universitario La Fe, Valencia, Spain b Laboratorio de Neurología Experimental, Centro de Investigación, Hospital Universitario La Fe; Valencia, Spain and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) c Servicio de Neurología, Hospital Santa Maria del Rosell, Cartagena, Murcia, Spain d Servicio de Anatomía Patológica,...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2014
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-014-1351-6